Abstract

Formulation and Evaluation of Pantoprazole Sodium Microspheres

Author: N.Sunitha

Doi: 10.62655/s-epub.2023.v15.i02.pp1-8

Abstract:

Microspheres are typically free flow powders consisting of proteins or synthetic polymers which are biodegradable in nature and ideally having a particle size less than 200 μm. An attempt was made to prepare floating microspheres of pantoprazole using polymers of PVP and HPMC by coacervaton technique. It was concluded that the drug release from the floating microspheres was controlled by the polymer. The nature of the polymers and their concentration influenced the physical and floating behaviour of the prepared microspheres. In vitro release data obtained from buoyant microspheres showed good buoyancy and prolonged drug release for formulations.