Abstract

Impact of the aqueous extract of the bark of Sclerocarya birrea on the lipid membrane structure hepatocytes Wistar rats

Author: Michodjehoun M. Clementine, Hoteyi Ismael,

Doi: 10.62655/s-epub.2021.v13.i01.pp1-4

Abstract:

The researchers in this work set out to analyse how different water-based extracts from the stem bark of Sclerocarya birrea affected the lipid membrane structure of hepatocytes in Wistar rats. We followed Bintou M.'s (2010) instructions to make an aqueous extraction using powdered dry bark of Sclerocarya birrea for this purpose. The biochemical testing of serum transaminase was the next step. An increase in serum transaminase levels indicative of hepatocyte necrosis is not induced by aqueous extracts of Sclerocarya birrea bark, according to our findings. The analysis of rat hepatocyte membrane lipid profiles using thin layer chromatography of lipids verified this, showing that hepatocyte damage might occur at high dosages (⩾200mg/kg) of an aqueous extract of Sclerocarya birrea stem bark. Because there was no discernible difference in lipid profile between the negative control and doses of 50 and 100 mg/kg of Sclerocarya birrea aqueous extract, it is safe to assume that this extract is hazardous at higher concentrations. Sclerocarya birrea aqueous extract is hazardous at concentrations of 200 mg/kg or above