Abstract

Influence of Circadian Rhythm In Radiation Induced Mucositis In Head And Neck Malignancies

Author: Dr. Vipin George Kuriakose

Doi: 10.62655/s-epub.2021.v13.i01.pp1-5

Abstract:

More than 60% of head and neck cancers in India are locally progressed. Treatment based on chemotherapy has been the mainstay for the last 30 years. Normal tissue toxicity, manifesting as mucositis, has remained a constraint despite the multimodal therapy.WHOLE SETTING AND APPROACH: Using data from patients undergoing radiation therapy for head and neck cancers, we looked at the possible links between the normal mucosal circadian cycle and the onset and progression of mucositis. We reviewed the records of 142 individuals diagnosed with squamous cell carcinoma of the head and neck (stage II to IVA) between time. There was a grading of patients according to whether they had EBRT first thing in the morning (8-11am) or last thing at night (5-8pm). Both groups exhibited a reasonable degree of homogeneity in clinicopathological features.